ABSTRACT
OBJECTIVE：To compare the eff icacy and safety of rivaroxaban versus enoxaparin in the treatment of malignant tumor complicated with venous thromboembolism （VTE），and to provide evidence-based reference to the clinic. METHODS ： Retrieved from PubMed ，Embase，Cochrane Library ，Clinical Trials ，CNKI，CBM and VIP ，clinical trials or observational studies about rivaroxaban versus enoxaparin were collected during the inception to Apr. 2020. After literature screening and data extraction ， the quality of included literatures were evaluated by Newcastle Ottawa scale ；Stata 15.0 software was used to conduct Meta-analysis，sensitivity analysis and publication bias analysis. RESULTS ：A total of 5 observational clinical cohort studies were retrieved，including 4 retrospective cohort studies and one prospective cohort study. Totally 997 patients were included ，among which 625 patients received enoxaparin and 372 patients received rivaroxaban. Results of Meta-analysis showed that there was no statistical significance in recurrence rate of VTE at 3 months follow-up [RR ＝0.91，95％CI（0.50，1.66），P＝0.760] and 6 months follow-up [RR ＝0.53，95％CI（0.24，1.15），P＝0.106] as well as the incidence of massive hemorrhage at 3 months follow-up [RR ＝ 1.22 ，95％CI（0.66，2.25），P＝0.530] and 6 months follow-up [RR ＝1.30，95％CI（0.73，2.33），P＝0.368]. The results of sensitivity analysis showed that the results of above Meta-analysis were stable ；the results of publication bias analysis showed that there was less possibility of publication bias in this study. CONCLUSIONS ：Rivaroxaban is as effective and safe as enoxaparin in the treatment of malignant tumor with VTE.
ABSTRACT
OBJECTIVE: To establish an HPLC method for simultaneous determination of vitamin B2 and folic acid in Multivitamin with Multimineral Tablets. METHODS: The samples were extracted with 0.5% (V/V) ammonia solution. An Alltima C18 column (4.6 mm × 250 mm, 5 μm) was used for the separation with 50 mmol · L-1 ammonium dihydrogen phosphate (adjusted pH to 3.0 with H3PO4) and acetonitrile (85-15) as the mobile phase at the flow rate of 0.5 mL · min-1. The detection wavelength was 282 nm. RESULTS: The method showed good linearity for vitamin B2 and folic acid with both correlation coefficients (r) greater than 0.9999 in the ranges of 11.52-34.56 and 2.952-8.856 mg · L-1, respectively; the specificity study showed satisfactory resolutions between vitamin B2, folic acid, other ingredients and forced degradation products; the precisions were satisfactory with both relative standard deviations (RSD) lower than 2.0%; the spiked recoveriesy at three levels ranged from 97.95% to 102.3% for both compounds; the stability at ambient temperature was acceptable within 8 h for both compounds in combined standard solutions and analytical solutions. Method comparison indicated coincident results between this method and the USP method. CONCLUSION: This method is an accurate, fast and simple method for the simultaneous determination of vitamin B2 and folic acid in Multivitamin with Multimineral Tablets. Copyright 2012 by the Chinese Pharmaceutical Association.